منابع مشابه
Stanley J. Korsmeyer
The scientific community has been saddened and diminished by the loss of Stanley J. Korsmeyer, M.D., who died of lung cancer last month at the age of 54. Over the last 25 years, Korsmeyer had been an international leader in the fields of cancer biology and programmed cell death (apoptosis). Through his studies of apoptosis, Korsmeyer helped revolutionize our concepts of carcinogenesis. Korsmeye...
متن کاملBy Stanley J . Korsmeyer , Philip a . Hieter ,
The maturation of a pre-B cell to an immunoglobulin (Ig)-bearing B cell requires an effective recombination of a light chain variable (VL) 1 and joining (JL) gene segment (1-11). Man uses both light chain gene classes appreciably, expressing K light chain in -60% and ~ light chain in 40% of mature B cells. Despite their nearly equal usage, however, the rearrangement of human Ig light chain gene...
متن کاملBeth Levine receives the 2014 ASCI/Stanley J. Korsmeyer Award.
Autophagy is an evolutionarily conserved process that degrades large cellular components and plays a critical role in maintaining cellular homeostasis. This year, the ASCI recognizes seminal work in the field by Beth Levine (Figure 1) of the University of Texas Southwestern Medical Center with its annual Stanley J. Korsmeyer Award. The prize honors Levine for her groundbreaking studies that fir...
متن کاملJean-Laurent Casanova honored with the 2016 ASCI/Stanley J. Korsmeyer Award.
Last year, Jean-Laurent Casanova published a landmark article in Science demonstrating that a child had life-threatening influenza because of genetic loss of interferon regulatory factor 7 (1). This paper provided the first evidence that severe influenza could be due to mutations in genes encoding factors that are specifically required for responding to influenza infection rather than mutations...
متن کاملBrian Druker and Charles Sawyers receive the 2011 ASCI/Stanley J. Korsmeyer Award.
Chronic myelogenous leukemia (CML) was the first cancer to be linked to a clearly defined genetic defect, a chromosomal translocation that generates a constitutively active tyrosine kinase. In the 1990s, Brian Druker and Charles Sawyers (Figure 1) collaborated to develop the targeted therapies that transformed CML from a fatal disease to one that boasts a 90% cure rate. Their work has been wide...
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ژورنال
عنوان ژورنال: Nature Cell Biology
سال: 2005
ISSN: 1465-7392,1476-4679
DOI: 10.1038/ncb0605-556